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Multiple subvariants are now being tracked: BA.2 → BA.4, BA.5, and others. Now the predominant variant worldwide.B.1.1.529 (Omicron) described November 2021 from samples taken in Botswana and S.As of July 2022, only one VOC so labeled. Variants of Concern ( VOC): defined as a variant with evidence of an increase in transmissibility, more severe disease (for example, increased hospitalizations or deaths), a significant reduction in neutralization by antibodies generated during previous infection or vaccination, reduced effectiveness of treatments or vaccines, or diagnostic detection failures. Variants Being Monitored ( VBM), more problematic earlier in the pandemic: concerning mutations identified but not widely circulating.Variants: four classifications per the WHO and CDC.Most notable for higher transmission rates than the ancestral strain increased virulence is less particular. The emergence of viral variants continues with rapid change.Severe infections remain more prevalent in the unimmunized and people with poor vaccine responses.BA.5 and BA.4 sublineage variants of Omicron are estimated to have a Ro 18.6, which approaches measles contagiousness and appears to have the most evasion of preexisting immunity.Omicron appears at least more transmissible than Delta, and Delta variant 50-70% more transmissible than earlier variants, including Alpha.Despite mitigation strategies, including facial masks and social distancing, vaccination, and therapies, surges of cases continue even among immunized populations in North America and Europe.
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Real-time global reports are available through Coronavirus COVID-19 Global Cases Dashboard by Johns Hopkins CSSE.It is unlikely this virus will disappear and likely become part of the repertoire of respiratory viruses that infect humans regularly. Ongoing pandemic, declared by the WHO.
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The viral envelope under electron microscopy appears crown-like due to small bulbar projections formed by the viral spike (S) peplomers.